Long-term weight gain in children with craniopharyngioma.
Sibylle RovaniVictoria ButlerDinane Samara-BoustaniGraziella PintoLaura Gonzalez-BricenoAdrien Nguyen QuocGaëlle VermillacAthanasia StoupaAlix BesançonJacques BeltrandCaroline ThalassinosIsabelle FlechtnerYamina DassaMagali ViaudMaria Beatriz Arrom-BranasNathalie BoddaertStéphanie PugetThomas BlauwblommeClaire AlapetiteStéphanie BolleFrançois DozJacques GrillChristelle DufourFranck BourdeautSamuel AbbouLéa Guerrini-RousseauAmaury LerusteKévin BeccariaMichel PolakDulanjalee KariyawasamPublished in: European journal of endocrinology (2024)
Clinically significant weight gain occurred in nearly all children treated for craniopharyngioma, including those whose hypothalamus was spared by the tumour and intentionally by treatment. However, hypothalamus integrity was associated with less weight gain. Despite hypothalamus-sparing strategies, hypothalamic obesity remains a major concern, indicating a need for novel treatment approaches.