Opioid Drug Detection in Hair Samples Using Polyoxometalate-Based Frameworks.
Maryam BazarganMasoud MirzaeiAmirhassan AmiriJoel T MaguePublished in: Inorganic chemistry (2022)
A series of two-dimensional (2D) polyoxometalate-based frameworks, [Ln 3 (PDA) 3 (H 2 O) 6 (PMo 12 O 40 )]· x H 2 O (Ln = La ( 1 ); Ce ( 2 ); Pr ( 3 ); Nd ( 4 ); PDA = 1,10-phenanthroline-2,9-dicarboxylate), have been synthesized and structurally characterized by various analytical techniques. Single-crystal X-ray diffraction reveals that 1 - 4 have a unique 2D layer structure in which Keggin anions have coordinated upward and downward the plane, and this feature makes them suitable candidates for surface binding of common drugs via supramolecular and electrostatic interactions. Also, the ability of 1 - 4 (as the first polyoxomolybdate-containing frameworks) as sorbents for the extraction and quantitative determination of opioid drugs (morphine, methadone, and pethidine) was investigated by using dispersive micro-solid-phase extraction (D-μSPE) and high-performance liquid chromatography (HPLC). The method showed wide linear ranges in the range of 0.3 to 300 ng mg -1 and low limits of detection (LODs) ranged from 0.1 to 0.2 ng mg -1 of hair.
Keyphrases
- solid phase extraction
- high performance liquid chromatography
- molecularly imprinted
- liquid chromatography tandem mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- simultaneous determination
- gas chromatography mass spectrometry
- chronic pain
- ultra high performance liquid chromatography
- pain management
- high resolution
- loop mediated isothermal amplification
- gas chromatography
- mass spectrometry
- label free
- machine learning
- real time pcr
- drug induced
- emergency department
- deep learning
- computed tomography
- transcription factor
- ionic liquid
- neural network
- ms ms
- metal organic framework
- molecular dynamics simulations
- electron microscopy
- atomic force microscopy
- binding protein
- dna binding
- dual energy
- high speed