Membranous Nephropathy following Full-Dose of Inactivated SARS-CoV-2 Virus Vaccination: A Case Report and Literature Review.
Theerachai ThammathiwatLaor ChompukSuchin WorawichawongVijitr BoonpucknavigSupinda SirilakSutatip PongcharoenWatchara PichitsiriTalerngsak KanjanabuchPublished in: Vaccines (2022)
Vaccination against the SARS-CoV-2 virus (COVID-19) has proven to be the most effective measure to prevent the spread and reduce infection severity. A case report of de novo membranous nephropathy (MN) following immunization with inactivated virus vaccine (CoronaVac ® , Sinovac Biotech) is presented here. A 53-year-old man presented with a sudden onset of leg edema a week after receiving an inactivated virus vaccine and a relapse of nephrotic syndrome (NS) with acute kidney injury (AKI) after a booster dose. Screening for serum anti-phospholipase A2 receptor antibody and secondary causes of MN were negative. Kidney biopsy revealed an early MN pattern with focal spike formation, whilst numerous subepithelial electron-dense deposits and a few small deposits in the mesangial area were observed through electron microscopy. A short course of steroids and oral cyclophosphamide was prescribed, resulting in the complete remission of NS and AKI. MN following SARS-CoV-2 vaccination should call for medical importance. Awareness of the association between vaccination and MN should be kept in mind to avoid unnecessary treatment with long-term immunosuppressive agents.
Keyphrases
- sars cov
- acute kidney injury
- respiratory syndrome coronavirus
- room temperature
- transition metal
- electron microscopy
- metal organic framework
- cardiac surgery
- low dose
- healthcare
- dengue virus
- coronavirus disease
- disease virus
- rheumatoid arthritis
- clinical trial
- diabetic nephropathy
- endothelial cells
- fine needle aspiration
- study protocol