Insulin clearance as the major player in the hyperinsulinaemia of black African men without diabetes.
Meera LadwaOluwatoyosi BelloOlah HakimFariba Shojaee-MoradieLinda BoselliGeoff Charles-EdwardsMarietta StadlerJanet L PeacockAnne Margot UmplebyStephanie A AmielRiccardo C BonadonnaLouise M GoffPublished in: Diabetes, obesity & metabolism (2020)
While normally glucose-tolerant BA men have similar insulin secretory responses to their WE counterparts, they have markedly lower insulin clearance, which does not appear to be explained by either insulin resistance or hepatic fat accumulation. Low insulin clearance may be the primary mechanism of hyperinsulinaemia in populations of African origin.