GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.

Wenjing ZhaoZiwei LiangYongshi YaoYang GeGuangyu AnLing DuanJiannan Yao

Published in: Cancer immunology, immunotherapy : CII (2024)

Our study identifies GGT5, a hub gene in GSH metabolism, as a potential therapeutic target for inhibiting the response to immunotherapy in GC patients. These findings offer new insights into strategies for optimizing immunotherapy of GC.

Keyphrases

end stage renal disease
signaling pathway
genome wide
newly diagnosed
chronic kidney disease
working memory
fluorescent probe
peritoneal dialysis
copy number
gene expression
human health
mass spectrometry
patient reported
tandem mass spectrometry