MANP Activation Of The cGMP Inhibits Aldosterone Via PDE2 And CYP11B2 In H295R Cells And In Mice.

Yang ChenSeethalakshmi R IyerViacheslav O NikolaevFabio NaroManuela PellegriniSilvia CardarelliXiao MaHon-Chi LeeJohn C Burnett

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Our results innovatively explore and expand the NP/pGC-A/3',5', cyclic guanosine monophosphate (cGMP)/PDE2 pathway for aldosterone inhibition by MANP in vitro and in vivo. In addition, our data also support the development of MANP as a novel ANP analog drug for aldosterone excess treatment.

Keyphrases

angiotensin ii
nitric oxide
induced apoptosis
protein kinase
cell cycle arrest
skeletal muscle
type diabetes
cell death
emergency department
metabolic syndrome
signaling pathway
insulin resistance