Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.

Nannan ZhaoShu YangBo SunYue FengRuqian Zhao

Published in: European journal of nutrition (2019)

Taken together, these results suggest that maternal betaine supplementation is effective in alleviating glucocorticoid-induced lipolysis in adipose tissue with modification of DNA methylation on the promoter of lipolytic genes.

Keyphrases

dna methylation
adipose tissue
genome wide
high fat diet
gene expression
high glucose
diabetic rats
insulin resistance
oxidative stress
copy number
transcription factor
pregnancy outcomes
metabolic syndrome
type diabetes
body mass index
skeletal muscle
weight loss