Viral and host factors drive a type 1 Epstein-Barr virus spontaneous lytic phenotype.

Katherine A WillardAshley P BarryCliff I OduorJohn Michael Ong'echaJeffrey A BaileyAnn M Moormann Micah A Luftig

Published in: mBio (2023)

Epstein-Barr virus (EBV) infects over 95% of adults worldwide. Given its connection to various cancers and autoimmune disorders, it is important to understand the mechanisms by which infection with EBV can lead to these diseases. In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. Because lytic replication of EBV has been linked to the pathogenesis of various diseases, these data could illuminate viral and host factors involved in this process.

Keyphrases

epstein barr virus
diffuse large b cell lymphoma
end stage renal disease
sars cov
ejection fraction
newly diagnosed
chronic kidney disease
escherichia coli
multiple sclerosis
prognostic factors
peritoneal dialysis
artificial intelligence
drug induced