Targeting nano drug delivery to cancer cells using tunable, multi-layer, silver-decorated gold nanorods.
Zeid A NimaAhmed M AlwbariVijayalakshmi DantuluriRabab N HamzahNatasha SraPooja MotwaniKonstantinos ArnaoutakisRebecca A LevyAmani F BohliqaDmitry NedosekinVladimir P ZharovIssam MakhoulAlexandru S BirisPublished in: Journal of applied toxicology : JAT (2017)
Multifunctional nanoparticles have high potential as targeting delivery vehicles for cancer chemotherapy. In this study, silver-decorated gold nanorods (AuNR\Ag) have been successfully used to deliver specific, targeted chemotherapy against breast cancer (MCF7) and prostate carcinoma (PC3) cell lines. Doxorubicin, a commonly used chemotherapy, and anti-Epithelial cell adhesion molecule (anti-EpCAM) antibodies were covalently bonded to thiolated polyethylene glycol-coated AuNR\Ag, and the resultant system was used to deliver the drugs to cancer cells in vitro. Furthermore, these nanoparticles have a unique spectral signature by surface enhanced Raman spectroscopy (SERS), which enables reliable detection and monitoring of the distribution of these chemotherapy constructs inside cells. The development of interest in a plasmonic nano drugs system with unique spectroscopic signatures could result in a clinical approach to the precise targeting and visualization of cells and solid tumors while delivering molecules for the enhanced treatment of cancerous tumors.
Keyphrases
- cancer therapy
- drug delivery
- raman spectroscopy
- cell adhesion
- gold nanoparticles
- reduced graphene oxide
- induced apoptosis
- locally advanced
- quantum dots
- cell cycle arrest
- silver nanoparticles
- highly efficient
- label free
- cell death
- gene expression
- visible light
- molecular docking
- chemotherapy induced
- papillary thyroid
- rectal cancer
- signaling pathway
- oxidative stress
- single molecule
- magnetic resonance
- climate change
- breast cancer cells
- drug induced
- combination therapy
- contrast enhanced
- walled carbon nanotubes