Pharmacokinetics of bedaquiline in cerebrospinal fluid (CSF) in patients with pulmonary tuberculosis (TB).

Caryn M UptonChanel I SteeleGary MaartensAndreas H DiaconLubbe WiesnerKelly E Dooley

Published in: The Journal of antimicrobial chemotherapy (2022)

Bedaquiline and M2 penetrate freely into the CSF of pulmonary TB patients with a presumably intact blood-brain barrier. Clinical studies are urgently needed to determine whether bedaquiline can contribute meaningfully to the treatment of CNS TB.

Keyphrases

blood brain barrier
mycobacterium tuberculosis
pulmonary tuberculosis
drug resistant
multidrug resistant
cerebrospinal fluid
cerebral ischemia
pulmonary hypertension
combination therapy
replacement therapy