Recent dynamics in Neisseria gonorrhoeae genomic epidemiology in Brazil: antimicrobial resistance and genomic lineages in 2017-20 compared to 2015-16.
Daniel GolparianMaria Luiza BazzoJosefine AhlstrandMarcos André SchörnerPamela Cristina GasparHanalydia de Melo MachadoJéssica Motta MartinsAlisson BigolinMauro Cunha RamosWilliam Antunes FerreiraGerson Fernando Mendes PereiraAngelica Espinosa MirandaMagnus Unemonull nullPublished in: The Journal of antimicrobial chemotherapy (2024)
Azithromycin resistance, mainly caused by 23S rRNA C2611T and mtrD mosaics/semi-mosaics, had substantially increased in Brazil. This mostly low-level azithromycin resistance may threaten the recommended ceftriaxone-azithromycin therapy, but the lack of ceftriaxone resistance is encouraging. Enhanced gonococcal AMR surveillance, including WGS, is imperative in Brazil and other Latin American and Caribbean countries.