Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study.
Britton TrabertSally B CoburnRoni T FalkJoAnn E MansonLouise A BrintonMargery L GassLewis H KullerThomas E RohanRuth M PfeifferLihong QiMarcia L StefanickNicolas WentzensenGarnet L AndersonXia XuPublished in: Cancer causes & control : CCC (2019)
These findings provide novel evidence that may support a heterogeneous hormonal etiology across ovarian cancer subtypes. Circulating estrogens did not influence endometrial cancer risk among women with EPT-induced high-estrogen levels. Larger studies are needed to delineate the relationship between ovarian/endometrial cancer subtypes and estrogen levels in the context of MHT use.