Long-term effects of somatostatin analogues in rat GH-secreting pituitary tumor cell lines.

A DicitoreD SaronniG GaudenziS CarraM C CantoneM O BorghiL PersaniGiovanna Mantovani

Published in: Journal of endocrinological investigation (2021)

Long-term incubation with PAS showed a more potent antitumor activity than that reported after OCT in GH3 cells, mainly modulated by a cell cycle perturbation and a relevant induction in apoptosis.

Keyphrases

cell cycle
cell cycle arrest
growth hormone
induced apoptosis
oxidative stress
cell proliferation
cell death
endoplasmic reticulum stress
pi k akt
optical coherence tomography
diabetic retinopathy
structure activity relationship