Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.
Rodrigo de Oliveira FormigaFlávia C AmaralCamila F SouzaDaniel A G B MendesCarlos W S WanderleyCristina B LorenziniAdara A SantosJuliana AntôniaLucas F FariaCaio C NataleNicholas M PaulaPriscila C S SilvaFernanda R FonsecaLuan AiresNicoli HeckMárick R StarickCelso M Queiroz-JuniorFelipe Rocha da Silva SantosFilipe R O de SouzaVivian V CostaShana P C BarrosoAlexandre MorrotJohan Van WeyenberghRegina SordiFrederico Alisson-SilvaFernando de Queiroz CunhaEdroaldo L RochaSylvie Chollet-MartinMaria Margarita Hurtado-NedelecClémence MartinPierre-Régis BurgelDaniel S MansurRosemeri MauriciMatthew S MacauleyAndré BáficaVéronique Witko-SarsatFernando SpillerPublished in: British journal of pharmacology (2022)
These findings suggest that NEU1-MMP-9 interplay induces neutrophil overactivation. In vivo, it was shown that NEU may serve as a host-directed target to dampen neutrophil dysfunction during severe infections.