Genomic landscape of locally advanced rectal adenocarcinoma: Comparison between before and after neoadjuvant chemoradiation and effects of genetic biomarkers on clinical outcomes and tumor response.

Tae-Hoon Lee Bum-Sup Jang Ji Hyun Chang Eunji Kim Jeong Hwan Park Eui Kyu Chie

Published in: Cancer medicine (2023)

Pre- and post-CRT samples showed different genomic landscape. Potential genetic biomarkers of pre-CRT samples found in the current analysis call for external validation.

Keyphrases

locally advanced
rectal cancer
copy number
neoadjuvant chemotherapy
squamous cell carcinoma
phase ii study
radiation therapy
genome wide
cardiac resynchronization therapy
single cell
left ventricular
risk assessment
clinical trial
heart failure
climate change