Analysis of lanthionine ketimine ethyl ester in mouse serum, whole blood and tissues using ultrahigh-pressure liquid chromatography/tandem mass spectrometry.
Ruth N MuchiriKatarzyna E KowalKenneth HensleyDouglas L FeinsteinRichard B van BreemenPublished in: Rapid communications in mass spectrometry : RCM (2018)
A rapid quantitative method to measure LKE in mouse serum, whole blood and brain tissues using UHPLC/MS/MS was developed and validated following FDA guidelines. This method is suitable for bioavailability and pharmacokinetic studies.
Keyphrases
- liquid chromatography tandem mass spectrometry
- ms ms
- simultaneous determination
- solid phase extraction
- gene expression
- high resolution
- high performance liquid chromatography
- tandem mass spectrometry
- ultra high performance liquid chromatography
- white matter
- resting state
- clinical practice
- multiple sclerosis
- cerebral ischemia
- brain injury
- gas chromatography