Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.

B KurzStephanie ArndtP UngerI IvanovaM BerneburgC HellerbrandSigrid Karrer

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

This study yielded a high frequency of functional SNPs in the NOD-2 and TLR-5 genes in PLE. The same SNPs are associated with aGvHD and there are similarities in the reaction of LCs after UVB irradiation between aGvHD and PLE. This leads to the hypothesis that patients with PLE may be more susceptible to developing GvHD after stem cell transplantation, an assumption that needs to be investigated further.

Keyphrases

high frequency
stem cell transplantation
genome wide
transcranial magnetic stimulation
toll like receptor
high dose
inflammatory response
immune response
dna methylation
nuclear factor
gene expression
innate immune
low dose
transcription factor
genome wide association
mass spectrometry
bioinformatics analysis