CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia.

Mica T M ClarkeAnn BrinkmalmMartha S FoianiIone O C WoollacottCarolin HellerAmanda HeslegraveAshvini KeshavanNick C FoxJonathan M SchottJason D WarrenKaj BlennowHenrik ZetterbergJonathan Daniel Rohrer

Published in: Alzheimer's research & therapy (2019)

No CSF synaptic proteins have been shown to be abnormal in those with likely FTD pathologically. Higher CSF synaptic protein concentrations of neurogranin, SNAP-25, and synaptotagmin-1 appear to be related to AD pathology.

Keyphrases

prefrontal cortex
protein protein
amino acid
cerebrospinal fluid
binding protein
cognitive decline
drug induced