Expression Profile of Sphingosine Kinase 1 Isoforms in Human Cancer Tissues and Cells: Importance and Clinical Relevance of the Neglected 1b-Isoform.

Hongjie ChenNahal HaddadiXiaofeng ZhuDiana HatoumSize ChenNajah T NassifYiguang Lin Eileen M McGowan

Published in: Journal of oncology (2022)

Our data suggest that SphK1a is important for generic SphK1/S1P functions, and SphK1b mediates specialized and/or unique pathways in a specific type of tissue and could be a biomarker for cancer. This discovery is important for future SphK1-related cancer research and may have clinical implications in drug development associated with SphK1-directed cancer treatment.

Keyphrases

papillary thyroid
squamous cell
endothelial cells
gene expression
induced apoptosis
small molecule
lymph node metastasis
squamous cell carcinoma
palliative care
childhood cancer
tyrosine kinase
electronic health record
young adults
signaling pathway
cell death