Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Paul BastardLindsey B RosenQian ZhangEleftherios MichailidisHans-Heinrich HoffmannYu ZhangKarim DorghamQuentin PhilippotJérémie RosainVivien BéziatJérémy ManryElana ShawLiis HaljasmägiPärt PetersonLazaro LorenzoLucy BizienSophie Touillet-AssantA Kerry DobbsAdriana Almeida de JesusAlexandre BelotAnne KallasteEmilie CatherinotYacine Tandjaoui-LambiotteJérémie Le PenGaspard KernerBenedetta BigioYoann SeeleuthnerJean-Laurent CasanovaAlexandre BolzeAndrás N SpaanOttavia M DelmonteMichael S AbersAlessandro AiutiGiorgio CasariVito LampasonaLorenzo PiemontiFabio CiceriKaya BilguvarRichard P LiftonMarc VasseDavid M SmadjaMélanie MigaudJérôme HadjadjBenjamin TerrierDarragh DuffyLluis Quintana-MurciDiederik van de BeekLucie RousselDonald C VinhStuart G TangyeFilomeen HaerynckDavid DalmauJavier Martinez-PicadoPetter BrodinMichel C NussenzweigStéphanie Boisson-DupuisCarlos FloresGuillaume VogtTrine Hyrup MogensenAndrew J OlerJingwen GuPeter Denis BurbeloJeffrey I CohenAndrea BiondiLaura Rachele BettiniMariella D'AngioBonfanti PaoloPatrick RossignolJulien MayauxFrédéric Rieux-LaucatEystein Sverre HusebyeFrancesca FuscoMatilde Valeria UrsiniLuisa ImbertiAlessandra SottiniSimone PagheraEugenia Quiros-RoldanCamillo RossiRiccardo CastagnoliDaniela MontagnaGian Luigi MarsegliaGian Luigi MarsegliaXavier DuvalJade Ghosnnull nullnull nullnull nullnull nullnull nullnull nullnull nullnull nullnull nullnull nullJohn S TsangRaphaela Goldbach ManskyKai KisandMichail S LionakisAnne PuelShen-Ying ZhangSteven M HollandGuy GorochovEmmanuelle JouanguyCharles M RiceAurélie CobatLuigi Daniele NotarangeloLaurent AbelHelen C SuJean Laurent CasanovaPublished in: Science (New York, N.Y.) (2020)
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Keyphrases
- respiratory syndrome coronavirus
- coronavirus disease
- sars cov
- dendritic cells
- immune response
- end stage renal disease
- systemic lupus erythematosus
- ejection fraction
- chronic kidney disease
- newly diagnosed
- multiple sclerosis
- middle aged
- polycystic ovary syndrome
- patient safety
- metabolic syndrome
- peritoneal dialysis
- quality improvement
- emergency department
- insulin resistance
- pregnant women
- dengue virus
- drug induced