Enhanced Cardiomyocyte NLRP3 Inflammasome-Mediated Pyroptosis Promotes d-Galactose-Induced Cardiac Aging.
Wen-Bin LiuSui-Sui WangXu ZhangZe-Zhi KeXiu-Yun WenJie ZhaoXiao-Dong ZhuangLi-Zhen LiaoPublished in: Journal of the American Heart Association (2024)
The reactive oxygen species/nuclear factor κ-light-chain enhancer of activated B cells/NLRP3 signaling pathway loop contributes to d-galactose-treated cardiomyocyte senescence and cardiac aging.
Keyphrases
- nlrp inflammasome
- nuclear factor
- high glucose
- reactive oxygen species
- signaling pathway
- toll like receptor
- endothelial cells
- left ventricular
- transcription factor
- angiotensin ii
- dna damage
- diabetic rats
- epithelial mesenchymal transition
- binding protein
- oxidative stress
- heart failure
- immune response
- drug induced
- newly diagnosed
- induced apoptosis