Adding Indoximod to Hypofractionated Radiotherapy with Anti-PD-1 Checkpoint Blockade Enhances Early NK and CD8+ T-Cell-Dependent Tumor Activity.

Tsubasa WatanabeSimone GaedickeElena GuffartElke FiratGabriele Niedermann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our findings may serve as a rationale for the clinical evaluation of this triple-combination therapy in patients with solitary or oligometastatic tumors in the neoadjuvant or the definitive setting.

Keyphrases

combination therapy
locally advanced
radiation therapy
rectal cancer
squamous cell carcinoma
dna damage
early stage
cell cycle
lymph node
clinical trial
radiation induced
nk cells
oxidative stress