Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism.
Maitray A PatelMichael J KnauerMichael NicholsonMark J DaleyLogan R Van NynattenClaudio M MartinEric K PattersonGediminas CepinskasShannon L SeneyVerena DobretzbergerMarkus MiholitsBrian WebbDouglas D FraserPublished in: Molecular medicine (Cambridge, Mass.) (2022)
Long-COVID patients suffer prolonged, diffuse symptoms and poorer health. Vascular transformation blood biomarkers were significantly elevated in Long-COVID, with angiogenesis markers (ANG-1/P-SEL) providing classification accuracy of 96%. Vascular transformation blood biomarkers hold potential for diagnostics, and modulators of angiogenesis may have therapeutic efficacy.