Multiple transcriptome analysis of Piwil2-induced cancer stem cells, including piRNAs, mRNAs and miRNAs reveals the mechanism of tumorigenesis and development.

Xiaojun TanTao MiZhaoxia ZhangLiming JinZhang WangXin WuJinkui WangMujie LiChenghao ZhanghuangDawei He

Published in: Molecular biology reports (2022)

PIWIL2-induced cancer stem cells have significantly altered levels of miRNAs, piRNAs and mRNAs.TGF-β, autophagy, apoptosis and other pathways may play an important role in stem cell development. The occurrence of alternative splicing and fusion genes may be related to the occurrence of cancer stem cells.

Keyphrases

cancer stem cells
stem cells
oxidative stress
diabetic rats
high glucose
risk assessment
endoplasmic reticulum stress
cell death
drug induced
genome wide
cell proliferation
dna methylation
genome wide identification