The Hippo pathway regulates photosensitivity in lupus skin.

Grace A HilePatrick CoitBin XuAmanda M VictoryMehrnaz Gharaee-KermaniShannon N EstadtMitra P MazJacob W S MartensRachael WasikowskiCraig DobryLam C TsoiRamiro Iglesias-BartolomeCeline C BerthierAllison C BilliJohann E GudjonssonAmr Hakam Sawalha J Michelle Kahlenberg

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

Our work unravels a novel driver of photosensitivity in SLE: overactive Hippo signaling in SLE keratinocytes restricts YAP transcriptional activity, leading to shifts that promote UVB-apoptosis.

Keyphrases

systemic lupus erythematosus
disease activity
wound healing
oxidative stress
endoplasmic reticulum stress
rheumatoid arthritis
cell cycle arrest
gene expression
cell death
transcription factor
soft tissue