Safety and Virologic Impact of Haploidentical NK Cells Plus Interleukin 2 or N-803 in HIV Infection.
Jeffrey S MillerJoshua RheinZachary B DavisSarah CooleyDavid McKennaJodi AndersonKevin Escandón-VargasGarritt WiekingJarrett ReichelAnn ThorkelsonSiri JorstadJeffrey T SafritPatrick Soon-ShiongGregory J BeilmanJeffrey G ChipmanTimothy W SchackerPublished in: The Journal of infectious diseases (2024)
There was a moderate decrease in HIV-producing cells in lymph nodes. Further studies are warranted to determine the impact of healthy NK cells on HIV reservoirs and if restoring NK-cell function could be part of an HIV cure strategy. Clinical Trials Registration. NCT03346499 and NCT03899480.
Keyphrases
- nk cells
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- clinical trial
- lymph node
- men who have sex with men
- induced apoptosis
- cell cycle arrest
- south africa
- high intensity
- low dose
- peripheral blood
- cell proliferation
- rectal cancer
- sentinel lymph node
- open label
- double blind
- placebo controlled