Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses.

Jer-Hwa ChangChao-Wen ChengYi-Chieh YangWan-Shen ChenWen-Yueh HungJyh-Ming ChowPai-Sheng ChenMichael HsiaoWei-Jiunn LeeMing-Hsien Chien

Published in: Journal of experimental & clinical cancer research : CR (2018)

CD26 may be a useful biomarker for predicting NSCLC progression. API effectively suppressed lung cancer progression by targeting the CD26-Akt-Snail/Slug signaling pathway.

Keyphrases

epithelial mesenchymal transition
signaling pathway
small cell lung cancer
pi k akt
cell proliferation
nk cells
advanced non small cell lung cancer