Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse.
Marion V GuerinFabienne RegnierMaxime ThoreauLene VimeuxMatthieu BenardEstelle DransartHweixian L PennyLudger JohannesAlain TrautmannNadège BercoviciPublished in: Journal for immunotherapy of cancer (2021)
Together, these results indicate that the local increase of IFNα in combination with an anti-PD1 therapy is an effective way to promote efficient and durable innate and adaptive immune responses preventing tumor relapse.