A prospective study into change of vitamin D levels, depression and frailty among depressed older persons.
Karen S van den BergJohanna M HegemanRob H S van den BrinkDidi RhebergenRichard C Oude VoshaarRadboud M MarijnissenPublished in: International journal of geriatric psychiatry (2021)
Our findings generate the hypothesis that vitamin D supplementation in late-life depression may improve frailty, which may partly explain inconsistent findings of randomised controlled trials evaluating the effect of vitamin D for depression. We advocate to consider frailty (components) as an outcome in future supplementation trials in late-life depression.