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AIKYATAN: mapping distal regulatory elements using convolutional learning on GPU.

Chih-Hao FangNawanol Theera-AmpornpuntMichael A RothAnanth GramaSomali Chaterji
Published in: BMC bioinformatics (2019)
Our exhaustive experiments using an array of ML tools validate the need for a model that is not only expressive but can scale with increasing data volumes and diversity. In addition, a subset of these datasets have image-like properties and benefit from spatial pooling of features. Our AIKYATAN suite leverages diverse epigenomic datasets that can then be modeled using CNNs with optimized activation and pooling functions. The goal is to capture the salient features of the integrated epigenomic datasets for deciphering the distal (non-coding) regulatory elements, which have been found to be associated with functional variants. Our source code will be made publicly available at: https://bitbucket.org/cellsandmachines/aikyatan.
Keyphrases
  • rna seq
  • high resolution
  • transcription factor
  • minimally invasive
  • electronic health record
  • copy number
  • single cell
  • high throughput
  • big data
  • machine learning