Stereospecific Construction of Quaternary Carbon Stereocenters from Quaternary Carbon Stereocenters.
Kaushalendra PatelVeeranjaneyulu LankeIlan MarekPublished in: Journal of the American Chemical Society (2022)
Organoaluminum species promote a smooth nucleophilic substitution at the quaternary carbon stereocenter of stereodefined polysubstituted cyclopropyl methyl phosphate with a complete inversion of configuration, even when more reactive functional groups are present. The regio- and diastereoselectivity of the substitution is attributed to the existence of a bicyclobutonium intermediate.
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