Prognostic Significance of Integrin Subunit Alpha 2 (ITGA2) and Role of Mechanical Cues in Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma (PDAC).

Alessandro GregoriCecilia BergonziniMjriam CapulaGiulia Mantini Fatemeh Khojasteh-Leylakoohi Annalisa ComandatoreGhazaleh Khalili-TanhaAlireza KhooeiLuca Morelli Soodabeh Shahidsales Erik H J Danen Thomas Schmidt Elisa Giovannetti

Published in: Cancers (2023)

ITGA2 emerged as a new prognostic factor, highlighting the relevance of stroma mechanical properties as potential therapeutic targets to counteract gemcitabine resistance in PDAC.

Keyphrases

prognostic factors
radiation therapy
human health
protein kinase