Effects of topical corticosteroid versus tacrolimus on insulin sensitivity and bone homeostasis in adults with atopic dermatitis-A randomized controlled study.

Lise Gether Heidi Storgaard Sanja Kezic Ivone Jakasa Bolette Hartmann Kirsa Skov-Jeppesen Jens Juul Holst Anders J Pedersen Julie Lyng Forman Gerrit V Hall Ole E Sørensen Lone Skov Mads Almose Røpke Filip K Krag Knop Jacob Pontoppidan Thyssen

Published in: Allergy (2023)

Whole-body treatment with TCS leads to systemic exposure but appears not to compromise glucose metabolism during short-term use, which may be a result of reduced systemic inflammatory activity. The negative impact on bone formation could be regarded an adverse effect of TCS.

Keyphrases

atopic dermatitis
oxidative stress
bone mineral density
emergency department
combination therapy
bone loss
postmenopausal women
replacement therapy