Is therapeutic anticoagulation improving renal outcomes in COVID-19?
Sohaib Sanan RoomiWaqas UllahSoban FarooqRehan SaeedShujaul HaqAmmar Ali AshfaqPublished in: Journal of community hospital internal medicine perspectives (2020)
We present three patients with COVID-19 who developed acute renal failure during hospitalization and were seen to have an improvement in their kidney function after being started on therapeutic anticoagulation with heparin (Target PTT 58-93 seconds) for varying indications (atrial fibrillation, popliteal vein thrombosis and a pulmonary embolism). Their kidney functions improved significantly following anticoagulation with a clear temporal relationship between the former and latter. Anticoagulation was held for one patient due to concern of gastrointestinal bleeding and his kidney functions worsened a day after stopping anticoagulation. D-dimer levels also improved with anticoagulation but the trend of other inflammatory markers remained unpredictable.
Keyphrases
- atrial fibrillation
- pulmonary embolism
- venous thromboembolism
- direct oral anticoagulants
- left atrial
- oral anticoagulants
- catheter ablation
- left atrial appendage
- coronavirus disease
- heart failure
- inferior vena cava
- percutaneous coronary intervention
- liver failure
- type diabetes
- left ventricular
- coronary artery disease
- case report
- adipose tissue
- metabolic syndrome
- aortic dissection
- insulin resistance
- acute respiratory distress syndrome
- respiratory syndrome coronavirus
- growth factor