Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation.
Hui-Jie ZhangBen-Hui WangXiang WangChun-Ping HuangSi-Man XuJia-Li WangTian-E HuangWan-Li XiaoXiao-Li TianXin-Qiang LanQi-Quan WangYang XiangPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Handelin ameliorated cachexia- and aging-induced skeletal muscle atrophy in vitro and in vivo, by maintaining homeostasis of protein synthesis and degradation, possibly by inhibiting inflammation. Handelin is a potentially promising drug candidate for the treatment of muscle wasting.