Antiapoptotic Effects of Hydroxychloroquine on Hypoxic-Ischemic Injury in Neonatal Rat Brain: May Hydroxychloroquine Be an Adjuvant Theraphy?

Tugay Tepe Mehmet Satar Hacer Yapıcıoğlu Yıldızdaş Mustafa Ozdemir Ferda OzlüSeyda ErdoganTugba ToyranKübra Akıllıoğlu

Published in: American journal of perinatology (2022)

· HCQ decreased neuronal apoptosis in the ischemic penumbra of the rat brain.. · HCQ attenuates hypoxia-ischemia-induced brain injury in neonatal rats.. · HCQ has no anti-inflammatory effect on HI injury..

Keyphrases

brain injury
cerebral ischemia
subarachnoid hemorrhage
anti inflammatory
oxidative stress
high glucose
early stage
diabetic rats
endoplasmic reticulum stress
endothelial cells
cell death
ischemia reperfusion injury
cell proliferation
signaling pathway