A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury.
Tien T TangJanice A ZawaskiShelli R KeslerChristine A BeamishWilburn E ReddickJohn O GlassDarrell H CarneyOmaima M SabekDavid R GrosshansM Waleed GaberPublished in: Neuro-oncology advances (2019)
These results demonstrate that CRT leads to late-term morphological changes, reorganization of neural connections, and metabolic dysfunction. The correlation between imaging markers and cognitive deficits can be used to assess late-term side effects of brain tumor treatment and evaluate efficacy of new interventions.