A novel combination of Soluplus®/Poloxamer for Meloxicam solid dispersions via hot melt extrusion for rapid onset of action. Part 2: comparative bioavailability and IVIVC.

Nesrin F Taha Maha F Emam Laila Hassanian Emara

Published in: Drug development and industrial pharmacy (2020)

Hot-melt-extrusion technology promises an ideal alternative for enhancing MLX extent of absorption compared to Mobic® with T max value almost equal to the reported intramuscular injection. Predictive IVIVC was established for in vitro dissolution profile and in vivo performance.

Keyphrases

ultrasound guided
loop mediated isothermal amplification
sensitive detection