Dysregulation of Gut Microbiota-Derived Neuromodulatory Amino Acid Metabolism in Human Immunodeficiency Virus-Associated Neurocognitive Disorder: An Integrative Metagenomic and Metabolomic Analysis.

Xue ChenJiaqi WeiZhen LiYang ZhangXin ZhangLing ZhangXia WangYulin ZhangTong Zhang

Published in: Annals of neurology (2024)

Our findings provide new insights into the intricate interplay between the gut and microbiome-brain axis in the pathogenesis of HAND, highlighting the potential for developing novel therapeutic strategies that specifically target the gut microbiota. ANN NEUROL 2024;96:306-320.

Keyphrases

human immunodeficiency virus
hepatitis c virus
amino acid
antiretroviral therapy
hiv infected
hiv aids
white matter
hiv positive
resting state
human health
antibiotic resistance genes
brain injury
functional connectivity