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Colorectal cancer and advanced adenoma characteristics according to causative mismatch repair gene variant in Japanese colorectal surveillance for Lynch syndrome.

Akiko ChinoKohji TanakayaTakeshi NakajimaKiwamu AkagiAkinari TakaoMasayoshi YamadaHideyuki IshidaKoji KomoriKazuhito SasakiMasashi MiguchiKeiji HirataTomoya SudoYasuyuki MiyakuraToshiaki IshikawaTatsuro YamaguchiNaohiro TomitaYoichi Ajioka
Published in: Journal of gastroenterology (2024)
In cases with path_MLH1, path_MSH2, and path_MSH6, maintaining an appropriate CS surveillance interval of within 2 years is advisable to detect of the colorectal lesion amenable to endoscopic treatment. path_MSH6 cases could be stratified with path_MLH1 and MSH2 cases in terms of risk of metachronous CRC and age of onset.
Keyphrases
  • public health
  • genome wide
  • case report
  • genome wide identification