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Defective renal autoregulation in the chronic bile duct ligation model of liver failure.

Tomchika MaokaTetsuya KawataTakao KoikeToshio MochizukiJurgen SchnermannSeiji Hashimoto
Published in: Clinical and experimental nephrology (2018)
Tubuloglomerular feedback (TGF) responses were significantly attenuated in BDL rats, especially in the subnormal flow range. Impairment of renal blood flow autoregulation, to some extent mediated by reduced TGF-mediated vasodilatation, may contribute to the renal vascular constrictor state in liver cirrhosis by preventing the full dilatory response to the blood pressure reduction.
Keyphrases
  • blood flow
  • liver failure
  • blood pressure
  • transforming growth factor
  • hepatitis b virus
  • type diabetes
  • heart rate
  • skeletal muscle
  • glycemic control