Human Macrophage Long Intergenic Noncoding RNA, SIMALR , Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1).
Esther CynnDaniel Y LiMarcella E O'ReillyYing WangAlexander C BashoreAnjali JhaAndrea S FoulkesHanrui ZhangHanna WinterLars MaegdefesselHanying YanMingyao LiLeila RossChenyi XueMuredach P ReillyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
partners with HIF1α (hypoxia-inducible factor 1 subunit alpha) to regulate NTN1, which is a known macrophage survival factor. This work illustrates the importance of interrogating the functions of human lncRNAs and exploring their translational and therapeutic potential in human atherosclerosis.