Natural killer cells in inflammatory autoimmune diseases.
Yuyan YangJessica DayFernando Souza-Fonseca GuimaraesIan P WicksCynthia LouisPublished in: Clinical & translational immunology (2021)
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof-of-concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell-targeted therapeutics.
Keyphrases
- nk cells
- multiple sclerosis
- systemic lupus erythematosus
- disease activity
- rheumatoid arthritis
- natural killer cells
- oxidative stress
- immune response
- induced apoptosis
- white matter
- ankylosing spondylitis
- mass spectrometry
- type diabetes
- cell cycle arrest
- ms ms
- glycemic control
- genome wide
- small molecule
- cancer therapy
- cell death
- interstitial lung disease
- cardiovascular disease
- gene expression
- skeletal muscle
- systemic sclerosis
- endoplasmic reticulum stress
- weight loss