18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition.
Kirsten M ReevesPatrick N SongAllyson AngermeierDeborah Della MannaYufeng LiJianbo WangEddy Shih-Hsin YangAnna G SoraceBenjamin M LarimerPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The results generated from this work provide an immediately translatable paradigm for measuring and targeting hypoxia to increase response to immune checkpoint therapy and using hypoxia imaging to guide combinatory therapies.