Sepsis endotypes identified by host gene expression across global cohorts.
Josh G ChenowethJoost BrandsmaDeborah A StriegelPavol GenzorElizabeth ChiykaPaul W BlairSubramaniam KrishnanElliot DogbeIsaac BoakyeGary B FogelEphraim L TsalikChristopher W WoodsAlex Owusu-OforiChris OppongGeorge OduroTe VanthaAndrew G LetiziaCharmagne G BeckettKevin L SchullyDanielle V ClarkPublished in: Communications medicine (2024)
Our analysis reveals details of molecular endotypes in sepsis that support immunotherapeutic interventions and identifies biomarkers that predict outcomes in these groups.