Staphylococcus aureus enterotoxin B disrupts nasal epithelial barrier integrity.
Katleen MartensSven F SeysYeranddy A AlpizarRik SchrijversDominique M A BullensChristine BreynaertSarah LebeerBrecht SteelantPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
SEB damages nasal polyp epithelial cell integrity by triggering TLR2 in CRSwNP. Our results suggest that SEB might represent a driving factor of disease exacerbation, rather than a causal factor for epithelial defects in CRSwNP. Interfering with TLR2 triggering might provide a way to avoid the pathophysiological consequences of S. aureus on inflammation in CRSwNP.
Keyphrases
- staphylococcus aureus
- toll like receptor
- inflammatory response
- immune response
- chronic rhinosinusitis
- chronic obstructive pulmonary disease
- oxidative stress
- nuclear factor
- escherichia coli
- biofilm formation
- cystic fibrosis
- methicillin resistant staphylococcus aureus
- extracorporeal membrane oxygenation
- mechanical ventilation