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Iodine(III)-Mediated C-C Bond Coupling to Construct Spirocyclic Indolenines of Various Ring Sizes.

Yanren ZhuShaoxiong YangEnfan PuLi LiSilei YeLongsheng WeiGuolan MaYushun ZhangHong-Bin ZhangJingbo Chen
Published in: Organic letters (2023)
Herein, we report a novel iodine(III)-mediated intramolecular dearomative spirocyclization of indole derivatives to generate highly strained spirocyclobutyl, spirocyclopentyl, and spirocyclohexyl indolenines in moderate to good yields. A set of structurally novel, densely functionalized spiroindolenines with broad functional group compatibility was efficiently constructed in this way under mild reaction conditions. Moreover, the β-enamine ester as a versatile functional group in the product provides great convenience for the synthesis of bioactive compounds and related natural products.
Keyphrases
  • dual energy
  • wastewater treatment
  • quantum dots
  • electron transfer
  • computed tomography
  • magnetic resonance
  • magnetic resonance imaging
  • high resolution
  • energy transfer
  • transition metal