Intracerebroventricular administration of the exercise hormone irisin or acute strenuous exercise alleviates epileptic seizure-induced neuroinflammation and improves memory dysfunction in rats.
Zarife Nigâr Ozdemir-KumralTuğçe AkgünCeren HaşimEzgi UlusoyMehmet Kaan KalpakçıoğluMuhammet Ferzan YükselTunahan OkumuşZeynep UsDilek AkakınMeral YükselZafer GörenTessa Corrine Catherina JaspersPublished in: BMC neuroscience (2024)
In conclusion, acute high-intensity exercise or exogenously administered irisin provides neuroprotection by maintaining the balance of excitatory/inhibitory neurotransmitters and oxidant/antioxidant systems.
Keyphrases
- high intensity
- resistance training
- liver failure
- drug induced
- respiratory failure
- oxidative stress
- anti inflammatory
- high glucose
- physical activity
- diabetic rats
- brain injury
- cerebral ischemia
- working memory
- hepatitis b virus
- cognitive impairment
- intensive care unit
- mechanical ventilation
- extracorporeal membrane oxygenation
- stress induced
- acute respiratory distress syndrome