A cell-autonomous mechanism regulates BCAA catabolism in white adipocytes and systemic metabolic balance.

Ashley M AguillardJoyce TzengIsmael FerrerBjorn T Tam Damaris N Lorenzo

Published in: bioRxiv : the preprint server for biology (2023)

Ankyrin-B deficits in adipose tissue result in elevated circulating BCAAs before the onset of obesity and insulin resistance.Ankyrin-B promotes the surface localization of the amino acid transporter Asct2 in white adipocytes and BCAA uptake.Excess BCAA supplementation worsens glucose tolerance and insulin sensitivity in ankyrin-B deficient mice.BCAA utilization by white adipose tissue is required for the obesogenic effects of BCAA overconsumption.

Keyphrases

adipose tissue
insulin resistance
high fat diet
high fat diet induced
amino acid
polycystic ovary syndrome
metabolic syndrome
type diabetes
traumatic brain injury
skeletal muscle
weight loss
body mass index
stem cells
glycemic control
weight gain