Porphyrin Macrocycles: General Properties and Theranostic Potential.
Rica BoscencuNatalia RaduleaGina MandaIsabel Ferreira MachadoRadu Petre SocoteanuDumitru LupuliasaAndreea Mihaela BurloiuDragos Paul MihaiLuis Filipe Vieira FerreiraPublished in: Molecules (Basel, Switzerland) (2023)
Despite specialists' efforts to find the best solutions for cancer diagnosis and therapy, this pathology remains the biggest health threat in the world. Global statistics concerning deaths associated with cancer are alarming; therefore, it is necessary to intensify interdisciplinary research in order to identify efficient strategies for cancer diagnosis and therapy, by using new molecules with optimal therapeutic potential and minimal adverse effects. This review focuses on studies of porphyrin macrocycles with regard to their structural and spectral profiles relevant to their applicability in efficient cancer diagnosis and therapy. Furthermore, we present a critical overview of the main commercial formulations, followed by short descriptions of some strategies approached in the development of third-generation photosensitizers.
Keyphrases
- papillary thyroid
- photodynamic therapy
- squamous cell
- healthcare
- public health
- lymph node metastasis
- mental health
- magnetic resonance imaging
- stem cells
- computed tomography
- optical coherence tomography
- childhood cancer
- climate change
- quality improvement
- young adults
- risk assessment
- bone marrow
- smoking cessation
- fluorescence imaging
- metal organic framework